Friday, October 05, 2007

ACE inhibitor may diminish cardiac complications with Marfan Syndrome

A preliminary research of 17 patients suggests that use of the ACE inhibitor perindopril (Aceon), reduced aortic stiffness and dilation in systole and diastole in patients with Marfan Syndrome taking standard beta-blocker therapy.

However the benefits of perindopril in improving cardic risks with Marfan Syndrome need to be established in larger groups and longer term clinical trials because the study was limited by its small size and relatively short duration.

Source: "Effect of Perindopril on Large Artery Stiffness and Aortic Root Diameter in Patients With Marfan Syndrome :A Randomized Controlled Trial" JAMA. 2007;298(13) :1539-1547

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